Hypervirulent Klebsiella pneumoniae: Characteristic and clinical perspective

Background: Hypervirulent K. pneumoniae (hvKP). A virulent pathogen that has the ability to infect individuals in various age, multiple ports of entry and cause infectious syndromes. Therefore urges an increase awareness perspective on characteristics clinical feature hvKP, better understanding providing appropriate treatment cases infection caused by hvKP. Main Text: (hvKP) was first reported Taiwan 1986. This bacteria responsible for liver abscess with septic endophthalmitis, these some patient have extrahepatic complications such as meningitis pneumonia, prostate pyogenic ophthalmia. There are several virulence factors hvKP as, capsule main defensive factor, aerobactin provide iron supply Colibactin can suppressing activity regulatory T lymphocyte cells, could improve survival avoid process phagocytosis, complement, antimicrobial peptides specific antibodies. The pathophysiology showed similar symptom conventional cKP except access syndrom. Conclusion: threat increases worldwide due more vary compared cKP. Consequently, special measures vaccine need be develop order eradicate this particularly among pediatric patient.